Molecular Immunopathogenesis and Antimicrobial Resistance in Enteric Fever: Mechanisms, Clinical Implications, and Emerging Therapeutic Strategies

About The Book

Molecular Immunopathogenesis and Antimicrobial Resistance in Enteric Fever provides an in-depth exploration of enteric fever, a major infectious disease caused primarily by Salmonella enterica serovars Typhi and Paratyphi A. Combining insights from microbiology, immunology, genomics, and clinical medicine, the book examines the molecular mechanisms that drive infection, disease progression, and antimicrobial resistance.
The text explores the biology and virulence of the pathogen, the complex interactions between host and pathogen, and the immune responses that influence disease outcomes. It explains how Salmonella survives within host cells, evades immune defenses, and causes systemic infection. The book also provides a detailed analysis of antimicrobial resistance, including genetic mutations, plasmid-mediated resistance, efflux systems, and the emergence of multidrug-resistant and extensively drug-resistant strains.
In addition, the volume discusses advances in vaccine development, host-directed therapies, and modern research methodologies such as whole-genome sequencing, RNA sequencing, and bioinformatics approaches. Designed for postgraduate students, researchers, clinicians, and public health professionals, this book offers a well-structured and evidence-based understanding of enteric fever and the evolving challenges it presents in global healthcare.

About The Author

Dr. Rimpa Manna Associate Professor, Facultyofscience and Facultyofparamedical, RKDF University, Bhopal, Madhya Pradesh, India Dr. Rimpa Manna is an accomplished academician and researcher with extensive expertise in medical microbiology, cytology, and molecular diagnostics. With a strong background in teaching and research, she has significantly contributed to the understanding of microbial pathogenesis and cellular pathology related to the female reproductive system.
In this book, “Cytology of Female Reproductive Tract”, Dr. Manna has played a vital role in conceptualizing and compiling key chapters focused on infectious and inflammatory cytopathology, sample preparation and staining techniques, and
molecular diagnostic approaches. Her work emphasizes the integration of classical cytological methods with modern microbiological and molecular tools for accurate disease diagnosis and research advancement.
Her academic contributions, combined with her dedication to medical education, make this book a valuable resource for students, clinicians, and researchers in the fields of cytology, microbiology, and reproductive health sciences.

Hirdesh Gour is an Assistant Professor at RKDF University Bhopal with over six years of experience in microbiology, clinical laboratory practice, and teaching. He holds a Master’s degree in Microbiology and a Bachelor’s degree in Medical Laboratory Technology, and is currently pursuing his Ph.D. in Microbiology.
With a strong academic and professional background in microbial sciences and diagnostic technologies, he has developed expertise in understanding infectious diseases, pathogen biology, and laboratory-based approaches to disease investigation. His experience as an Assistant Professor and clinical technologist has contributed to his interest in bridging fundamental microbiological mechanisms with clinical applications.
His academic interests include microbial pathogenesis, host–pathogen interactions, antimicrobial resistance, and emerging therapeutic strategies against infectious diseases. Through this book, he aims to provide a comprehensive understanding of the molecular mechanisms underlying enteric fever, immune responses, antimicrobial resistance challenges, and evolving approaches for improved disease management.